Friday, April 13, 2018

Marxian Octopus


CHAIRMAN BOWDITCH: Our first speaker this afternoon, as compared with some of those whom we heard this morning, is a relative newcomer to industrial medicine. Following periods of private practice and general medicine in the Army, he had his first industrial work in the Plastics Division of the duPont Company at Arlington, New Jersey, and is now medical director of the Electric Storage Battery Company in Philadelphia.

Dr. Francis B. Lanahan will speak on Preventive Medical Armor for the Lead Industry.

Preventive Medical Armor for the Lead Industry

By Francis B. Lanahan, M.D.

Medical Director, Electric Storage Battery, Co., Philadelphia, Pa.
November 1948

I should like to preface my prepared presentation by a few remarks which I am stimulated to make in light of the tone of the discussions which preceded the luncheon period. My relative youth and brevity of experience in industrial medicine prompts me to make the obvious remark, that my position here at this microphone draws heavily on the courage of my convictions. At Philadelphia, the Electric Storage Battery Company has two plants. We have, to our conviction, over 2,000 people

With that preface to describe the environment that my presence here represents, I should like to present this for your consideration.

Purges are known chiefly within the walls of Communistic domination. Ulcerations on the body of nations inflicted by extended arms of the Marxian Octopus as excised by healing Christian action. Curative or destructive are today's searching forces.

Curative and constructive are the aims of The Electric Storage Battery Medical Division in Philadelphia. Preventive medical principles form the foundation of the Division's reorganization instituted one year ago. Assessment of all established procedures was instituted. On the body of the Preventive Medical Program, lead control methods hung like a withered aim, helpless to prevent illness.

Though harsh is our criticism of established methods, sincere is our admiration for investigators who applied these methods in the light of past knowledge. It is believed these same investigators with their proven abilities will, with the stronger light of present knowledge, lead the industry forward into the arena of preventive medicine.

As our present control methods are known to be common to the lead industry in general, our convictions and corrective measures are presented here for general consideration.

Entering the field of lead toxicology, we carried deep rooted convictions concerning the soundness of preventive medical principles and the wealth of benefit they hold for industry. We looked for methods of control indicative of levels of lead absorption within limits compatible with health. Methods in use were found to be non-specific of lead absorption and demonstrative of existing tissue damage. Invariably, the horse was out of the barn. Nor did we know which horse to look for. When analytical methods were resorted to, it was for specific diagnostic purposes; indeed, too late with too little for preventive medical aims. We found the use of hemoglobin determinations, stippled cell counts and physical examinations established as the medical methods of choice, and we followed them, lacking knowledge of better means. These revealed established disorders of structure and function.

Lead in air determinations were in use. These necessarily were brief and infrequent when related to the individual's total work exposure. They could not reflect negligent working habits. Hygiene instructions fell on torpid health attitudes as on the well known duck's back. The knowledge that these methods and working habits were widely existent in the lead industry gave small and unwanted consolation. To establish preventive medical principles a wide chasm appeared before us. It was the void between lead exposure and toxic lead absorption, between results of spot air samples and actual lead absorption during the total work period, influenced by negligent working habits.

It was the darkness obscuring failing tissue defenses of the worker whose prolonged exposure to generally safe environment could be causing insidious damage. A bridge was needed to span the chasm and give firm footing for the preservation of health. Nature is found to give the bridge. An instrument of the Divine Scientist, human metabolism, spans the chasm. The man on the job is the best impinger and precipitator of the lead to which he is exposed. His period of collective samples represents his total working period. His faulty working habits are reflected. These facts are recorded in analytical studies of his excretions.

The direct relationship between atmospheric and oral lead contamination and lead excretion in blood, urine and feces has been revealed by the meticulous studies of Dr. Robert Kehoe and his associates at the Kettering Laboratory. Ranges of excretions related to casual and to occupational exposures and compatible with health have been indicated by them.

Criteria for dealing with workmen on the planes of their lead absorption and excretion have been established by them on the basis of long experience. The use of these analytical studies are known to all of us. Essentially, our application of them has been for diagnostic purposes. When we have been alarmed by anemia, high stipple count or clinical evidences of disorders which could mean lead intoxication, we have resorted to them.

Few of us have applied the analytical measures as preventive controls. Known outstanding exceptions have been the programs developed by Dr. Hamlin in the American Brake Shoe Corp. and in the Ethyl Corp., but to a lesser degree in certain other industries, by Dr. Kehoe. The majority of us have placed the burden of our negligence on the complexity of analytical procedures. We can no longer afford to retain our present methods in the guise of lead control. We must recognize them for their inadequacy as preventive measures and resort to them in their true function as secondary diagnostic tools. This change is forced upon us by the present availability of a simplified, rapid analytical method to determine lead in urine spot samples.

This is the procedure described by Dr. Jacob Cholak and his associates at the Kettering Laboratory in the January, 1948 number of the Journal of Industrial Hygiene and Toxicology. Though rapid, the method demands studied care to avoid contamination and technical errors. Yet, it is practical within the abilities of all of us who are determined to strive for the highest plane of medicine and hygiene.

It is our purpose to use this method for the regular observation of our workmen. Relying generally on spot urine samples, we will study larger volumes or frequent spot samples of urine in the event a single spot result suggests an increasing range of excretion.

When high range of excretion is indicated by the additional studies, samples of blood and urine will be obtained for more precise analysis.

As the rapid method is known to confuse bismuth with lead, it will be routine to inquire of any medication being taken by the workers. The incidence of bismuth in the routine studies is expected to be small. When high values are obtained, the longer method of analysis will be employed, thus excluding bismuth or any other metal than lead.

To minimize contamination of the samples by work clothing it is planned to collect the samples before work clothes are worn or after showers. Collection of samples at the beginning of a shift is likely to exclude high concentrations or dilutions of the samples. Equipment necessary to apply the use of the rapid method is approximated to cost $3,000. As the analyses must be made in an atmosphere free of lead, the cost of air conditioning a room in the production area would have to be accounted. A 500 sq. ft. area is considered adequate for the analytical laboratory. A technician working under the supervision of a chemist can make 30 to 40 determinations daily. To avoid phosphate precipitation, the samples must be analyzed as soon as possible after they are voided and always within 24 hours. A general survey of the plant by this method will establish the mean excretory levels of the men working in specific areas. On this basis a schedule of interval studies can be established. Attending to necessary precision, the ease with which the analyses can be made will allow for a flexibility of the scheduled studies to check variations in production methods and environmental factors.

This routine applicable to group studies will be applied to individual workmen whose excretory levels fail to conform to mean group values. Air analyses will be used to accomplish its present purpose but it will gain a firmer footing of usefulness in distinguishing the atmospheric factor of contamination in suspected environments.

The suspicion will have been cast by high mean values among the workmen of the particular area. Should our facilities and the personnel permit us to develop our own analyses by the longer methods, as has been shown to be practical by Dr. Hamlin and Mr. Weber of the American Brake Shoe Corp., the combined equipment is judged to cost about $10,000.

As in the general field of industrial medicine, small plants with limited budgets can share the benefit of this quality of medicine and hygiene by pooling their needs and spreading their expenses through the use of centrally located industrial clinics.

The qualification of such existing clinics for our particular need or the stimulus to develop them is a fertile field of activity for the Lead Industries Association.

As we progress toward the accomplishment of our program we do so with the stimulating conviction that our efforts will establish a regimen of preventive medical control which will — Keep men fit for their jobs and jobs fit for men.

CHAIRMAN BOWDITCH: The principal discussion of Dr. Lanahan's paper will be by a man from whom you heard this morning. He is a specialist in industrial medicine and toxicology of many years' standing, a member of the Committee on Lead Poisoning of the American Public Health Association, associate professor of medicine at Marquette University and consultant to Globe-Union. Inc. and to a number of other industries and insurance companies. Dr. Elston L. Belknap.

DR. ELSTON L. BELKNAP [Globe-Union, Inc., Milwaukee, Wis.]: Mr. Bowditch, members of the Lead Industries Association, friends and co-workers: I believe that Dr. Lanahan is to be congratulated for his convictions and his determination to approach this in a very basic way. I wonder, and perhaps he can answer me shortly, whether his method of urine examination, spot samples and group samples, will replace the time-honored method of physical examinations for lead lines, blood studies for hemoglobin, types of red cells, stipple cells and history, or whether it is used to supplement it. I am interested to know how soon, also, he thought he could recheck his workers with this method.

For instance, if he has 2,000 workers and 40 can be done a day, it would take about fifty days before he could get back and re-check a worker. Perhaps he will supplement that with the other usual forms of treatment in the meantime. My experience with lead in the urine has been to get it, if possible, about twice a year on a lead worker, preferably a twenty-four hour urine that has been collected at home, away from the plant. It is then studied by the Fairhall modification of the chromate method, which, though it takes three or four days, we have felt from experience has been the most fundamentally safe procedure because it is primarily an analytical chemical method. I understand that Dr. Fairhall has modified this so that the analysis can be done in a matter of hours. This, I believe, will answer the objections to this method.

It seems to me the question comes back to this. When you have done an examination of lead in the urine, what do you have? Do you have a diagnosis of lead poisoning or do you have a diagnosis of lead absorption? Certainly, the Public Health Committee, of which Dr. Kehoe is chairman, specifically said that no one laboratory finding made the diagnosis of lead poisoning and, as already has been brought out here by a number of speakers, including Dr. Mayers, whom I have always admired primarily for her ability as a clinician, that one must view the patient as a whole. No one should attempt to make a diagnosis of lead poisoning by any one laboratory finding. I have seen workmen who have become ill with relatively low urine leads.

The man that I mentioned this morning, for instance, I believe had about — 0.25 mg. of lead with no symptoms, and the day he got in the hospital, he had 0.14 mg. of lead per litre of urine. I do not believe that that was the result of any magical treatment that he received in that interval. I think that is simply the variation in urine findings that one must expect in these cases.

On the other hand, I have seen men working for thirty years in the storage battery industry with urine values as high as 0.5, 0.6 and 1.0 mg. of lead per litre of urine, who have never been disabled, ill, lost any time and have shown no anemia, who have had no wristdrop, no lead encephalopathy.

They have normal blood pressure and a normal routine urine. One such man is still turning out a good day's work at the age of sixty-five, and he dates back to the time when conditions were not as we would desire them, when 25 years ago, 75 percent of the men had evidence of heavy lead absorption. We know also that our lead in the air at times is much more than it should be, 3, 10, 12, 15, 18 mg. per 10 cu. feet. Of course, we have corrected that now with air line respirators using as much suction at the source of the dust as possible. In modern production methods, even when you are improving a situation, often the worker has to use the respirator.

Of course, no one can deny if the respirator is used continuously and no effort is made to correct conditions of lead exposure, it is a confession of engineering weakness. If you wish, however, to keep men from being sick, I am afraid you are going to use respirators occasionally in the storage battery industry while protective suction equipment is being fitted into production. In fact, if that man I was talking about this morning, could have a job found for him, and I think it can be found, where he is using not an ordinary respirator which he is likely to discard, perhaps, because he does not get enough air through it, and is given an air-line respirator, that would be just the same to me as if he were moved out from the lead exposure. I have done that again and again, and the man is still making good money and he is satisfied; the company is satisfied, because he goes on and continues his convalescence even while working. We covered this morning, I think, what constitutes lead poisoning or true lead intoxication. Lead absorption is one thing; disabling lead intoxication is another. We are not using those terms to escape any responsibility. We are simply wanting to be precise, as we like to be in any field of medicine.

A sign of lead absorption, certainly, is lead line, a finding which can be easily determined by spot illumination, even a flashlight, or better still, a head mirror and a small hand lens which costs about ninety-five cents, incidentally. One can then definitely say there is or there is not a deposit of linear or round row of dots in the gum tissue next to the teeth.

Of course, one should know that the individual has not been taking bismuth for the treatment of syphilis. Otherwise, the physician cannot rule out the fact that the apparent lead line may be a bismuth line. I believe I have seen some perfectly marvelous lead lines that excited me then I found out when the Wasserman report came back and after a little private conference with the individual, that he was getting bismuth as treatment for syphilis. In fact, some of the men doing syphilology insist that a patient is not receiving sufficient bismuth unless he shows a bismuth line.

One does not always see a lead line if a man has good teeth. A case that I had had perfect teeth and showed no lead line until after he was disabled. The pyorrhea, decay and detrius around teeth seem to be a precipitate of what is apparently lead sulfide in the gum. However, that is merely an evidence of lead absorption. Certainly, if there is no bismuth to be confused with, and if one sees a lead line, one knows that the worker has had too much lead absorption and the physician should be on his guard regarding a possible disabling lead intoxication. That is fully as important to me as the determination of the lead value in the urine. It is certainly a good deal less expensive.

In doing medical work in industry, one has to learn to fit in with production schedules. The men are not always anxious to come in for periodic re-examinations even though it may be on company time, and the company is not too anxious to have them. However, I want to see the men as often as necessary. That may be every day in some cases, though usually every two weeks and in some cases every month or three months, depending on the concentration of exposure. But to make an examination of the man for a lead line, to talk to him, really to get that patient-doctor relationship that Dr. Johns spoke about this morning, to take his blood pressure and to make a note and record the facts is usually a matter of only a very few minutes.

Then, if one's technician is working at the same time on another group of men and gets the hemoglobin and the stippled cells, one can fit, as you see, right into production. Nobody warms the chair very long. But we have our information, and we see the man as often as we need to in our best judgment. We have men who have been having their ears stuck for blood every two weeks, for twenty years, and, if we miss them, we hear from them. If we forget to call them in, they come in complaining, "Why don't you call me in?" That is something you would not expect, but those old-timers know the conditions that were there before we started this system, and they know that it pays to have this medical observation. So much for lead line, which is a simple procedure and which I should like to illustrate presently. Like a lead line, a few stippled cells, say, 5 to 10 per 50 fields, are also an indication of lead absorption but are not likely to mean lead intoxication. They are much simpler to study than lead in the urine. Lead in the urine is extremely valuable in mass group studies. It is valuable for research purposes and, certainly for medico-legal cases for doubtful cases.

I hope I have intimated that I have no quarrel with people who are interested in doing lead in the urine. I think that it is a valuable and helpful adjunct, but as Dr. Fairhall has said, urinary lead excretion is one of six cardinal factors in the diagnosis of lead poisoning and, standing by itself, a urinary lead indicates nothing but lead absorption. I should like to emphasize the symptoms of lead intoxication. As I said this morning, if a man is sick, if he is really ill, if he is weak, if he is nauseated and vomiting, and if he has a real constipation or occasionally if he has diarrhea, and even more rarely, if he has a fleeting arthralgia, or joint pains, with all the other factors, if we know that he has been exposed to lead, if he shows evidence of lead absorption in some one of those ways, with those symptoms, plus a rising stippled cell curve, then we know that he probably has true lead poisoning. Then it is just and wise to admit it to the patient promptly and tell him what he has and see that he gets immediate relief. Fortunately, relief can be given to the most severe type of violent lead colic in 20 to 30 minutes after the injection of calcium gluconate.

I am especially interested in trying to make this clear to you today because this is what I try to make clear to my medical students and what we also try to make clear to the doctors in our county and state medical societies. The doctors are the harder problem, incidentally.

We make the distinction between lead absorption and lead intoxication, because, in a perfectly sincere manner, the average doctor who, perhaps, has seen one or two cases of lead absorption and intoxication in his life, if any, even in medical school, often relies primarily on the statement of his patient, "Yes, I work with lead." "What do you mean you work with lead?" "I work with paint." "What kind of paint?" "I don't know. All paint has lead, hasn't it?" Unfortunately, the doctor does not always pursue that type of questioning until he is forced to on the witness stand, and then it is somewhat embarrassing to him as a physician to admit his error in being led astray by his patient.

In our State our Industrial Commission examiners are often called on to act as attorney for an applicant, and I have heard them go through that questioning before a hearing comes to pass. If the applicant cannot answer intelligently, they say, "You have no case. Go find out what kind of paint you are working with." If the doctor has the facts he should speak with authority but the average doctor does not realize that he is regarded by a layman as an authority. One of our problems is to make the average physician realize the weight that is put upon his words. A patient often comes to him and says, "Doctor, I have been working with lead, and I have a bellyache. Don't you think I have lead poisoning?" The physician often replies, "Well, I don't know; perhaps you have," and then passes it off. He does not even think of the possibility of this going to court. He finds a little anemia, with or without stippled cells: he may not even look for lead line and probably forgets to have a urine lead. Then suddenly he finds himself called up to a court hearing and he has to make good the mistaken idea the patient had, that his physician thought he had lead poisoning. Such a physician is in for a bad half-hour on the stand, with a competent cross-examination by an experienced attorney.

The physician, if he wishes to speak with authority, must make his diagnosis one that will stand up not only in court but that he could get up and argue for before his county medical society. There is the jury of his true peers, and every word he says to them has to stand the severest kind of scrutiny.

Even though he knows that he cannot make a diagnosis on one laboratory finding alone, he must depend on exposure, plus the following facts: There must be evidence of lead absorption shown in the urine and gums or a few stippled cells. There must be actual signs of intoxication, usually a disabling colic and usually terrific constipation, obstipation, we call it, which does not respond to any cathartic. That makes up the ordinary kind of lead intoxication. Ninety per cent of the cases are lead colic. Hunter, of England, has said that there are ten times as many lead colic cases as lead palsy cases. Most of us see very few lead palsy cases, fortunately. I have seen, perhaps, half a dozen in twenty-five years.

When we have looked at this thing from the point of view of industrial exposure, then we have to go at it from the standpoint of differential diagnosis.

Does this man have a gallbladder colic? Does he even have a coronary occlusion referred pain to the abdomen? Does he have a pancreatitis? Does he have kidney colic? And, in the case of a palsy case, are we dealing with, perhaps, an alcoholic, or infectious neuritis? It is a helpful sign that with most cases of lead palsy, there is no pain, and the palsy is primarily extensor rather than flexor.

I have gone into some detail on this because the usual physician has not had experience with this type of industrial exposure. By and large, by his own admission, the average doctor knows very little about it except what he reads in the textbooks. These, in many cases, are perhaps twenty years behind the times.

The problem, then is one of education of our young physicians as well as education of the laymen, of management and of the worker to distinguish the points I have been making.

In regard to residuals, in my experience, the 90 percent of the cases which go to make up lead colic come through without any permanent residual. True, they may have temporary anemia. The lead palsy cases may have a residual, but not always, if treated properly.

Lead encephalopathies, the third and rarest of the three types of lead intoxication, may have a serious residual, if they recover at all,
such as mental involvement, but, again, they may come through, as did some of the ethyl-fluid cases, without any residuals at all. I would not like to leave anybody with the impression that we do not meet lead poisoning anymore in modern industry. I agree with Dr. Johnstone, that in the small industry we are likely to have it all the time. It frequently appears in unusual places in many small plants.

The accompanying photographs show how we go in what we think is a 1, 2, 3 manner.

[caption] Fig. 1--The old and new method of inserting separators between storage battery plates.

Fig. 1 — I show this photograph of inserting separators between storage battery plates because I think any layman who has never done anything with lead — and the average doctor has to be regarded as a layman in this area — can tell, by looking at the left-hand picture, that conditions in that picture are not nearly as good as they are in the right-hand picture. You can see in the picture on the left-hand side that a plank has been thrown on the floor; lead dust can fall on the plank and be kicked up and inhaled. In the right-hand picture there is a slotted rack so the dust falls through to the floor where it will not be kicked up as dust and then can be washed down at the end of the working day. In the right-hand picture again we have slotted down-draft suction tables. I think you can see for yourself that that man on the right has a much safer job. In spite of that, we insist that they wear respirators, whenever possible, though, practically, the engineering precautions there have cut the lead exposure remarkably.

[caption] Fig. 2--The definite, punctate deposit of lead sulphide appearing as small black dots, in the mucous membrane next to the teeth.

Fig. 2 — Often we have the problem as to diagnosis of a lead line. "Doctor, have you ever seen one?" Some doctors admit that they have not, but I think this picture proves that there is such a thing. You see here the definite, punctate deposit of lead sulphide in the mucous membrane next to the teeth. The dirt and detritus stippled cells which is quite enough often to be associated with disabling lead colic.

Figs. 4 and 5 — This periodic re-examination chart gives you an idea of the value of recheck studies. These examinations are made about every two weeks with the date at the top; then at the side the particular symptoms that we are looking for, either weakness, headache, drowsiness, if there was a brain involvement and the usual gastrointestinal symptoms, such as constipation or colic.

We do watch the weight though the weight does not give any specific information, only to indicate something as to the general physical condition of the man. Then we test each man for extensor weakness of the wrist at the same time we are taking his blood pressure and looking at his teeth. Teleky, I think, was the one who brought out most clearly the importance of testing the extensors prophylactically. We make a note as to the pallor, the number of teeth opposite which there is a gum lead line, and the strength of the wrist extension. We observe the blood pressure finding also because we are interested in finding whether these cases are going to go on and develop an increased amount of hypertension and arteriosclerosis as some have alleged in the older literature. To date we have not seen that in our experience.

At the bottom of the chart we have a place to record stippled cell count and the hemoglobin. In one particular case, early in the.


[caption] Fig. 3 — Photomicrograph showing stippled blood cells.



[Missing Page 51-52, probably mostly figures, with a small amount of text leading up to page 53 here:]

and the hemoglobin. In one particular case, early in the game, when we did not take warning quick enough, he was running 10, 21, 30, 110, 217 stippled cells and we still let him stay on the same job. He began with diarrhea, which was an intestinal influenza, and at first he had no lead line. Then he suddenly blew up with constipation and afterwards he had his lead line.

The anemia was a late development here. That is the most important thing. I think, in the blood picture regarding lead. We all agree that lead stippling, or stippling of red cells is not a specific indicator for lead absorption or intoxication. You may find it with Hodgkin's disease. Benzol poisoning, tumor, malignancy, any type of severe anemia, will eventually show nucleated red and stippled cells, but with the lead intoxication, you get your stippled cell rise early, long before the hemoglobin drops.

In this case he did not have his drop to 65 and 60 hemoglobin until after he was disabled. If we had been relying on the hemoglobin, we would have allowed him to go a lot further than we did, absorbing even greater amounts of of lead.

Following calcium gluconate intravenously, the patient went back to work and worked for two or three years. He was in excellent physical condition before he left our employ. He went back to the same type of work, incidentally, but with a respirator. The particular man had been working at a job where nobody thought he had a lead exposure. He was working in the forming room, normally a wet room, but he was the one man in the department who was dropping dry plates into a battery case. He did not show up for examination until he got sick. We did not like that; we like to be able to put our finger on these cases of impending intoxication three or four months ahead of time.

I think I should like to close with the statement that there is no short cut to clinical medicine. As Dr. Mayers has said, every single case has to be viewed as a whole, from the viewpoint of general differential diagnosis, and one must study the whole picture, not any one laboratory finding, not even stippled cells alone. Knowing these things to be frets, we can, with good conscience, go about our job of keeping the worker healthy and at work.

CHAIRMAN BOWDITCH: We are so behind schedule that I think we had better confine our further discussion to a brief reply by Dr. Lanahan, if he so wishes. Anything more can be at the end of the afternoon, if we have time.

DR. LANAHAN: Dr. Belknap posed several questions in relation to my presentation. The one that strikes me as most important is whether or not we plan to use urine lead determinations to make our diagnoses of intoxication, or resort to other measures. He has touched on the heart of what I feel is our presentation. The problem of which we are intolerant in our present program is that it is a diagnostic program. When we apply our proposed analytical studies as we are determined to apply them and are faced with a diagnostic problem, we will admit to ourselves that we have failed somewhere along the line, foiled in prevention.

Our persuasion to head in this direction is based on the studies that have been made by Dr. Kehoe and others who have established the ranges of blood and urine lead levels that are compatible with health, that are seen in people with known occupational exposure, accepting these ranges as our starting point. We hope to keep our people within a range of lead excretion compatible with such standards. As we see them working their way above such standards, we hope to make more extensive studies to catch the bugs in our rapid method. At this stage we feel that we will be ahead of clinical symptoms and stipple cell changes. We will be before the stage of diagnostic procedures, using preventive methods. Dr. Belknap has asked, if urine determinations will replace physical examinations. As I mentioned in the preface to my presentation, in spite of, let's say, the abundance of our medical personnel, we feel that we are not able to watch our people as intimately as necessary to prevent diagnostic problems.

We are looking for something which will give us a signpost by which we can have our fingers on everyone before they become diagnostic problems, and we hope that our proposed method is the measure by which we may accomplish this.

When we find groups, and the individuals within the groups, having excretory ranges above those which have been declared as compatible with health, we will resort to our present program of physical examinations and complete blood studies, repeating them as frequently as we wish. Again, let me say, when we have a diagnostic problem, we will admit that our preventive medical program has a hole in it.

Dr. Belknap asked how soon we can plan to review these people, if it requires one technician for 30 or 40 determinations daily?

Our present program, which I have described as involving study of stippled cells, hemoglobin determinations and personal communications with these people, entails the entire activity of two laboratory technicians. We estimate that it takes them 20 minutes for each technician lo do each laboratory study, which results in the determination of the hemoglobin and the stippled cell count. We believe urine studies will involve no greater lime and will require no additional technical personnel.

Our chemist, who at present does our lead in air determinations, can oversee the precision of our laboratory analytical studies, for I do not presume to be so qualified. I might add this. In Fig. 1, Dr. Belknap presented to you the picture of an assembly line, with grating in the floor and the down-draft in the table. Men were wearing respirators.

It is my routine to accompany the general safety committee which, incidentally, is a management-labor coordinated committee, in visiting every procedure throughout both plants once a month. I would love to find that each time we passed the assembly line and any other process we had, we would see our men actually wearing respirators, where they have been issued.

The respirator is either, obviously, down on his chest or it is in a position where he can quickly duck his nose under it as we are going by.

We have down-draft; we have water under the grates, and we have respirators. Our air levels worry us. We have people getting sick. We are doing what all of you are doing, and we are not satisfied with it.

CHAIRMAN BOWDITCH: This seems an appropriate moment to repeat Mr. H. J. Weber's very excellent definition of the industrial respirator. He has aptly described this device as "A muzzle type ornament worn loosely pendant from the neck, used in dirty industries to distinguish the laborers from the office employees."

I am sorry that we cannot continue this discussion further at this time, for I know that there are one or two others who could contribute valuably to it, but we must get on ...

Friday, November 27, 2015

Life Is Nothing Unless You are Lead Poisoned

"Life is nothing unless you are obsessed." -- John Waters

If the curve fits, wear it! -- Me

Sunday, January 25, 2015

Quietly We Stopped Poisoning You

OK, Once in a While We Made A Little bit of a fuss
admitting we had been using poison solder to seal food cans but now our product was new and improved with a lead solder-free can so everything is cool and we are sorry if you became insane or retarded from eating from the older cans we made.

Friday, November 14, 2014

US National Peak Oil Clobbered Tetraethyl Lead

The US CDC ATSDR states that 1970 was the peak year for tetraethyl lead in gasoline.
Toxicological Profile for Lead - Section 8 Regulations and Advisories. 
By 1988, the total lead usage in gasoline had been reduced to <1% of the amount of lead used in the peak year of 1970 Superfund Amendments and Reauthorization Act (SARA) (EPA 1996a).
But the EPA etc. didn't do anything about reducing tetraethyl lead use in 1971.  US National peak oil and the third Middle East oil embargo against the US did that.

In Jan 1973 the EPA ruled that by 1974 unleaded gas was to be available. In Dec 1973 they ruled that lead had to start being phased down. This fails to account for lead levels falling from 1970 to 1973. The fact that tetraethyl lead usage did not increase in 1971, 1972 and 1973 must have had a cause since until then every year brought more cars and more gasoline.

This paragraph from the EPA shows the timeline for the phase down:
US EPA Persistent Bioaccumulative and Toxic (PBT) Chemical Program
... skip ...
6.2.1 Regulations Controlling Use

In the early 1970s, EPA issued two regulations under the statutory authority of the 1970 Clean Air Act (CAA). First, EPA required major gasoline retailers to begin selling one grade of unleaded gasoline by July 1, 1974. This mandate was primarily focused on preventing the deterioration, as a result of leaded gasoline, of emissions control systems (e.g., catalytic converters) in motor vehicles so equipped. In developing these regulations, EPA first established the working definition of "unleaded" gasoline as "gasoline containing not more than 0.05 gram of lead per gallon and not more than 0.005 gram of phosphorus per gallon" [38FR1255, January 10, 1973]. Second, EPA issued a regulation calling for the gradual phase-out of leaded gasoline. The schedule for reduction of lead content in automobile gasoline was 1.7 grams per gallon (g/gal) in 1975, to 1.4 g/gal in 1976, 1.0 g/gal in 1977, 0.8 g/gal in 1978, and 0.5 g/gal in 1979 [38FR33741, December 6, 1973]. Subsequent regulations reduced the allowable lead content to 0.1 g/gal in 1986 [50FR9397, March 7, 1985], and prohibited leaded gas use after 1995 [61FR3837, February 2, 1996].
That article quotes Federal Regulations (the ##FR#### codes) that can be seen here: Electronic Code of Federal Regulations - PART 80—REGULATION OF FUELS AND FUEL ADDITIVES US National peak oil happened in December 1970, the most productive month of all time at 308,264,000 barrels/month. See US DOE EIA - U.S. Field Production of Crude Oil
The third Middle East embargo came online in October 1973
The Oil Weapon and American Foreign Policy - Dr. Joseph S. Szyliowicz Major Bard E. O’Neill
... the decision by the Organization of Arab Petroleum Exporting Countries (OAPEC) in October 1973 to decrease the production of crude oil and to embargo the U.S. ...


Saturday, October 25, 2014

Tetraethyl Lead Production in the 1930s at Frose (Saxon-Anhalt) and Gapel-Döberitz near Premnitz (Land Brandenburg)

U.S. Strategic Bombing Survey: Oil Division, 2d ed. - United States. War Dept 1947


Table A15
Tetraethyl Lead and Ethylene Dibromide Production Available to Germany (Approximate)

(Metric Tons per Month)

Tetraethyl LeadEthylene Dibromide
Gapel*
Germany
Frose#
Germany
Paimboeuf
France
TotalTornesch
Germany

Capacity production100300200600500**
1942December10030044444235
1943January10030042442362
February10030053453406
March10030094494434
April10030076476167
May100300117517236
June10030054454278
July100300120520210
August1003003643630
September10030060460380
October100300614610***
November100300384380
December1003008748766

For 1943 total 5638 metric tonnes.

5638 * 2204.6226 = 12,429,662.2188 pounds.


CW DISPOSAL IN THE FORMER GDR    p. 185

There were production facilities for the nerve agent lead tetraethyl (anti-knock) at Frose (Saxon-Anhalt) and Gapel-Döberitz near Premnitz (Land Brandenburg).  These facilities were included in the munition disposal activities in the GDR owing to the fact that, in the 1930s, the British considered lead tetraethyl and other lead-organic compounds to be potential chemical warfare agents.  The USSR demolished these two production plants in a crude fashion, leaving behind destroyed facilities contaminated with extremely toxic lead tetraethyl and equally toxic by-products13, but detailed information of these activities is not available. A 300-400 tonnes sludge residue, consisting of lead oxide and 1-5 per cent lead tetraethyl, is estimated to have remained.

The difficult and dangerous work of detoxification and removal was carried out by specially trained workers.  Chemical breakdown of the contaminated matter in the drainage conduits, pipes, settling tanks and soil was achieved with a 1:1 mixture of sulphuryl chloride and kerosene.  The resulting pasty sludges of lead oxide, lead sulphide and lead chloride were deposited in a landfill.  One of these former production sites is again in operation producing leaded fuel compounds for civilian use.

4. Lohs, K. Synthetische Gifte [Synthetic poisons], 1st edn (Verlag des Ministeriums für Nationale Verteidigung: Berlin, 1958), 4th edn (Militärverlag der DDR: Berlin, 1974); Lohs, K. and Martinetz, D., Entgiftung und Vernichtung chemischer Kampfstoffe [Decontamination and destruction of chemical warfare agents] (Militärverlag der DDR: Berlin, 1983); Stöhr, R., Die chemischen Kampfstoffe [Chemical Warfare Agents] (Deutcher Militärverlag: Berlin 1961); and Chemische Kampfstoffe und Schutz vor chemischen Kampfstoffen [Chemcial warfare agents and protection against chemical warfare agents] (Militärverlag der DDR: Berlin, 1985).

13. Müller, K., 'Zur Kasuistik der Bleitetraethylvergiftung' [On the cause of tetraethyl poisoning], Zentralblatt für Arbeitsmedizin und Arbeitsschutz, vol. 3 (1974), p. 9. See also Lohs (note 4), pp. 179-84.



OK. 12.4 million pounds of tetraethyl lead, much of it burned in the engines of aircraft which spewed their exhaust like lead crop dusting all happening in a country maybe the size of Texas, not to mention storage and distribution done under desperate conditions. Did anybody get any lead poisoning from all of that mess?


Monday, October 20, 2014

Early Tetraethyl Plant Demonstrates The Potential Dangers


TETRAETHYL LEAD FATAL TO MAKERS


An Industrial Peril Which the Washington Inquiry Into Gasoline Does Not Cover.

8 DEAD, 300 ILL, IN 1 PLANT

Dangers in Producing the Chemical Compound Shown in Record at Deep Water, N.J.

DEATHS SINCE PLANT CLOSED

Illness Begins With Hallucinations of Butterflies and Terminates in Violent Insanity and Death.

Deaths in Tetraethyl Gas Production at a Single Plant

  1. Sept. 21, 1923--FRANK W. DURR, 37 years old, dye worker; died at Penns Grove, N.J.; attended by Dr. Raymond B. Jarratt.
  2. July 30, 1924--JOSEPH CIANCI, 24 years old, dye works operator; died at Salem (N.J.) Memorial Hospital; attended by Dr. Harry W. Lee.
  3. Aug. 12, 1924--FRAN HANLEY, 23 years old, dye worker; received at Salem Hospital with gastric ulcer and underwent operation but then went insane subsequently from tetraethyl lead poisoning; attended by Dr. F. H. Church.
  4. Oct. 20 1924--SIM JONES, 47 years old, negro janitor at plant; died in Salem Hospital; attended by Dr. Lee.
  5. Feb 13, 1925--FREDERICK W. DeFIEBRE, 21 years old, dye worker; died at Salem Hospital; attended by Dr. Lee.
  6. Feb 16, 1924--ROBERT F. HUNTSINGER, 35 years old, dye worker; died at Cumberland County Hospital for the Insane at Bridgeton, N.J.; attended by Dr. E. C. Lyon.
  7. Feb 28, 1925--LORING M. BOODY, 53 years old, carpenter; died at Carney's Point, N.J.; attended by Dr. Lee.
  8. March 27, 1925--JAMES CONNELL, 49 years old, millwright; died at home in Wilmington, Del.; attended by Dr. James A. Draper

By SILAS BENT. [June 22, 1925]

Eight workers in the du Pont tetraethyl gas plant at Deep Water, near Penns Grove, N. J. have died in delirium from tetraethyl lead poisoning in eighteen months and 300 others have been stricken, but not fatally. Whatever the findings of Surgeon General Hugh S. Cumming's committee on the distribution and use of "antiknock" gasoline treated with the compound, the full record of fatalities, now made public for the first time, reveals afresh the hazards of its industrial production. The plant has been closed since April [1925].

Four of the deaths at Deep Water have occurred this year, three in a single month, while State and Federal authorities were still investigating the disaster of last October in the Standard Oil's Bayway plant near Elizabeth, N.J., in which five lost their lives. The poisonings this year of du Pont employees occurred in a new million-dollar plant, after two years of experience in production and presumably after the experimental stage had passed. The Federal committee of seven appointed by Dr. Cummings, however, is not concerned with this industrial phase. It is directed to report on the commercial phase by Jan. 1. "if possible".

The first cases of tetraethyl lead intoxication known to medical science developed in September, 1923, at the du Pont plant, and baffled famous neurologists who were consulted. One of the early symptoms is a hallucination of winged insects. The victim pauses, perhaps while at work or in a rational conversation, gazes intently at space, and snatches at something not there. The employees at Deep Water have ironically dubbed the plant "The House of the Butterflies."

The list of dead presented herewith was officially verified at the du Pont headquarters in Wilmington, Del., on Friday. Dr. A. K. Smith, chief of the medical staff, says that the 300 cases mentioned do not include those slightly affected. Some were merely hysterical from anxiety. About 80 per cent of all who worked in "The House of the Butterflies," or who went into it to make repairs, were poisoned, some repeatedly.

One Other Death in Doubt.

The du Pont officials said that the list of eight which I resented was complete and that there had been no other deaths from tetraethyl at Deep Water. No report had been made to them, it was said, regarding John Demesse, a plumber, who died last Sept. 11 at Delaware Hospital in Wilmington after doing some work in the plant. The death certificate gives typhoid as the cause.

Mrs. Mary Casey of 606 Spruce Street, Wilmington, a cousin of Demesse and his closest relative in this country, told me of a conversation with Dr. Lawrence J. Rigney, whom she called into the case.

"He said there were typhoid germs in the body." she explained, "but that John's lead poisoning didn't help him any."

Efforts to reach Dr. Rigney were unsuccessful. Not he, but Dr. John R. Russo, a member of the hospital staff, signed the death certificate. When asked about the symptoms of the Demesse case he said he had no recollection of it, and he reported several hours later that he could find no record of it at the hospital. The death certificate gave no contributory cause of death, nor was there any answer in the certificate to the question: "Where was disease contracted if not at the place of death?" This space was left blank.

Demesse was a widower, 35 years old. At du Pont headquarters the point was stressed that if poisoning had contributed to his death his relatives would have demanded a settlement.

Death After Three Attacks.

The first tetraethyl poisoning of medical record was that of Harry A. Zanes, now 53 years old, who lives at 97 I Street, in Carney's Point, an industrial town owned by the du Ponts adjoining Deep Water. He became ill on Sept. 9, 1923, and went to the emergency hospital maintained by the du Ponts on their reservation of six square miles across the Delaware River from Wilmington, where the chemical and smokeless powder plants are grouped. After treatment he went back to work, but a week later had to go home. He couldn't eat, and on the rare occasions when he slept he suffered from frightful nightmares. On Sept. 19 he became violent and two trained nurses were assigned to care for him.

"The patient has twitching muscular contractions," the nurses recorded: "respiration rapid, pulse shallow," And a little later: "Patient's head is thrown back rigidly: thinks some one is after him to kill him." And the: "Patient's pupils dilated; grinning and gritting teeth." A little later he was put into a straitjacket after he became so violent he could not be held in bed.

Zanes was ill three months and was under the care of Dr. A. R. Lynch, then a member of the medical staff on the reservation. When Zanes was able to work again he was assigned for a time to another plant, but returned to tetraethyl production and was poisoned again. In September of last year it happened a third time. These were much slighter attacks, although the man became delirious.

"The last time he didn't know it was lead he was working with." said Mrs. Zanes, "and Dr. Lynch raised a stink about it at the plant."

The testimony of nearly all the persons I saw, however, was that the du Ponts exercised every precaution possible to safeguard their employees from the deadly stuff they were handling.

First Fatality of Old Employee.

Frank W. (Happy) Durr, 37 years old, who had worked for the du Ponts since he was a lad of 12, was the first employee to succumb. The was ill only a short while and died in a straitjacket on Sept. 21 1923, at his home in Penns Grove. There was no story about it in his home paper, and none elsewhere, although the Penns Grove Record displayed in a half-column account on the first page the facts about Otto J. (Snapper) Barkdull who was accidentally killed by electricity in the plant two days after Durr's death.

Thomas C. Sumerill, editor of The Record, said he did not remember the circumstances. "I guess the reason we didn't print anything about Durr's death was because we couldn't get it." he explained. "They suppress things about the lead plant at Deep Water. Whatever we print we pick up from the workmen."

Durr's widow who lives now with here mother at Woodstown, ten miles east of Penns Grove, told me that Barkdull had worked at he plant only two months, whereas Durr had been employed by the du Ponts for twenty-five years.

At that time the du Ponts were producing tetraethyl lead in what has been a dye works. In July 1924 there was a death from poisoning, another in August, another in October. Work was already underway on a five-story brick structure 85x150 feet in size, to be opened on Jan. 1 of this year.

Special Care for the Afflicted.

All the men who died and who were on the tetraethyl force were classified in the death certificates as "dye workers" or "dye operators." The reservation known as "the dye works" is in fact, aside from the powder mills (where 25,00 men were employed at the peak during the war in the production of smokeless powder) a congeries of poison plants. Phosgene and chlorine gases as well as toxic benzol series, are manufactured there.

In the old tetraethyl plant there was a series of explosions and fires which occurred from chemical reactions while the autoclaves, huge mixing vats, were being emptied or cleaned. From these there were no deaths, but there were many injuries. C. D. Porch, superintendent of the plant, was himself badly burned and some of the chemists required medical treatment. Arrangements were made with the Salem (N. J.) Memorial Hospital, to which the du Ponts give annual contributions, to care for patients from Deep Water, and such cases have been its chief source of revenue. An executive of "the dye works" is on the hospital's Board of Managers

All the men who died in 1924, and one in 1925 were under treatment at this hospital. They were hard to manage on account of their violence, and the du Ponts, in addition to paying all medical expenses and providing for the families, sent male nurses to attend and restrain the patients.

An official of the hospital told me that Joseph Cianci, the victim in July, a man of great strength, had actually by his insane violence overturned the bed to which he was strapped; but Miss Hanna B. Harris, Superintendent, denied this.

"I've seen him actually lift the bed three or four inches off the floor by his struggles," she said, "but I'm sure he was never as bad as that."

Miss Harris did not admit at first that Frank Hanley's death in August was due to tetraethyl poisoning.

"He had an ulcer of the stomach and underwent an operation." she explained. But when she was told that the death certificate specified "acute intoxication lead tetraethyl" she was silent but later admitted it. As a fact the man escaped some time after the operation form the hospital to the street and was caught there. At du Pont headquarters it was admitted that this was a case of poisoning.

Sim Jones, negro janitor at "The House of the Butterflies." work old shoes and absorbed the poison through his feet. It is fatal if inhaled or taken through the skin in sufficient quantities. In all, Miss Harris said, forty-eight cases were treated at Salem. Sim Jones was the last to die there in 1924.

Thought Danger Averted.

Jones died on Oct. 20, about the time the series of deaths in the Standard Oil plant at Bayway centered public attention on the startling consequences of tetraethyl poisoning An official of the Ethyl Gasoline Corporation said publicly that the du Ponts had been having trouble too; and Irénée du Pont, President of the E. I. du Pont de Nemours Company, issued on Oct. 30, ten days after Sim Jones died, the following statement:

Tetraethyl lead, which the du Pont Company is manufacturing on a commercial scale, and which is reported as the cause of the recent unfortunate accident at the Bayway plant of the Standard Oil Company should not be confused with ethyl gas, an improved motor fuel which contains less than one-tenth of 1 per cent of tetraethyl lead.

Tetraethyl lead is poisonous, and its manufacture involves risk but no more than many chemicals manufactured and used in enormously greater amounts.

The du Pont Company, during the experimental period experienced much trouble with men becoming poisoned even to the extent of fatalities. During the past year of production, when more than 100 men have been employed continuously, the difficulty has diminished steadily. In the past several months, under full production, only slight difficulties have been encountered. Experience has taught the necessary protection, both in plant and medical care.

We find that workmen cumulatively poisoned by this material invariably indicate it in the incipient stages, before any harm is done, by a marked symptom. Doctors in the employ of the company continually make tests on workers engaged in this process.

Later Precautions Futile.

In "the past several months" to which Mr. du Point referred as causing "slight difficulties," there had been three deaths. There were no more fatalities until the following February, after work had begun in the new plant, where special precautions had been taken. In that month three workers died.

A change was made in the process of manufacture. Prior to this the ethyl for the compound had been introduced in the form of ethyl bromide; but the bromine required for this ingredient is costly to manufacture and difficult to procure in quantities sufficient for such commercial operations as the du Ponts had in view. The chemists decided to try ethyl chloride instead. Chlorine, a greenish-yellow and extremely poisonous gas, can be manufactured in huge quantities.

Frederick W. DeFiebre, a worker, 21 years old, was the first to die on Feb. 21, from poisoning in the new plant. To the Salem Hospital this is an ambulance run of but twenty minutes, and Dr. Harry W. Lee, chief surgeon of the du Pont staff at Deep Water, rushed the patient thither for treatment.

Even before this death Robert F. Huntsinger, 35 years old, had become ill and had insisted on going to his home .... nty miles away in ... He lived there at ... When he became violently insane Dr. E. C. Lyon who was treating him and who is the county physician took him to the Bridgeton Hospital where it was found that the patient's condition was such he would not be cared for. Then he was taken to the Cumberland County Hospital for the Insane where six men were required at times to restrain him. He died there Feb. 16 two days later. Dr. Lee went from Deep Water to help Dr. Lyon attend the patient.

A reporter for a Bridgeton newspaper asked the county physician whether he would ask for an inquest. "No," said Dr. Lyon, "it was not an accident. It was an occupational disease, and there is no occasion to call in the Coroner."

Plant Closed Soon Afterward.

Dr. Lyon, who repeated this statement to me, was warm in his praise of the du Ponts for the care they exercised in behalf of their employees. The facts about the death were printed in the Bridgeton newspapers, and the inquiries were made regarding it at du Pont headquarters. A statement was issued by the publicity department in which after giving the facts of his illness, it was said:

"Meanwhile the company, because of his illness and the illness of Fred W. Fiebre [DeFiebre], a laborer who later died, has shut down the plain to make modifications to insure greater manufacturing safety. * * * The du Pont Company experienced trouble with men becoming poisoned in the early stages of the manufacture of this chemical, but for a year difficulties have diminished steadily and for the past several months, under full production, only slight trouble had been encountered until these recent fatal illnesses occurred."

The plant had, as a fact, been closed by order of Dr. Andrew F. McBride of Paterson, chief of the New Jersey State Labor Commission. Dr. McBride had been conducting a State-wide inquiry into the manufacture, use and transportation of tetraethyl lead. In the latter part of November he reported to Governor Silzer that no more of the poison should be manufactured.

The plant was closed five weeks before Dr. McBride gave permission to reopen it. Meanwhile the du Ponts spent $60,000 making mechanical adjustments and installing a new ventilating system, whereby warmed and moistened air within the plant is changed every forty seconds in order to reduce the danger.

Two Deaths After Plant Closed.

The last fatalities were of a millwright and his helper, who were poisoned while making some repairs and died after the plant was closed. These were James Connell, who died at his home in Wilmington, and Loring M. Boody, who died at Carney's Point, on the du Pont reservation.

Boody, the helper, was attended by Dr. Lee of the du Pont staff, and the death was attributed in part to uremic poisoning. The day before Boody's death Connell went home ill, and died on March 27. In regard to both these cases the du Pont Publicity Bureau gave out items to the Wilmington daily newspapers which are owned by the du Ponts.

Regarding the four deaths which have occurred this year, therefore, there has been scattering publicity. The fact of Huntsinger's death at Bridgeton was reported in the New York newspapers. But even before these deaths occurred there were persistent rumors of trouble at Deep Water; and last November it was reported and printed that there had been nine deaths, although at that time there had been but four.

C. K. Weston, who is at the head of the du Pont Publicity Bureau, said that the earlier deaths were not treated as news because, until after the Bayway tragedy, there was no public interest in such occurrences.

Dangers Soon Revealed.

"The complete list of deaths from the Deep Water plant is now in the hands of Dr. McBride," he added. "We have told the facts and it is absurd to say that the du Ponts have suppressed anything, or that they subsidize hospitals. As a matter of custom they contribute small sums to all the hospitals which are near their plants and which are likely to be asked to treat patients. The contribution this year to Salem Hospital was only $500; but, of course, in addition to that the company pays, and pays well, for the treatment of its patients.

"Our people themselves did not know about this disease at first, but the physicians quickly learned to cope with it. We began manufacturing tetraethyl lead about three years ago, and one of the doctors said to me once that he had never known an industrial malady which flew the red flag so quickly.

"The du Ponts are well known for their interest in their employees. They spare no expense to protect the health and lives of their men, and when one is hurt or loses his life, the company pays, in New Jersey and every other State where it has properties, higher compensation and pension rates than the law requires. It is a fact that we have a great deal of trouble inducing the men to be cautious. We have to protect them against themselves."

Mr. Weston had heard of the workers' name for the plant.

"Some of them drew pictures of butterflies on the walls of the plant." he said. "This disease is somewhat like delirium tremens. Instead of seeing snakes the men see butterflies."

Danger in Gas, Not Gasoline.

Since production began 300,000,000 gallons of ethyl gasoline have been distributed in twenty-eight States, from 12,000 filling stations with no record of poisoning or ill-health from its use, according to Mr. Weston. The name "looney gas" is deceptive, in his view, in that it may apply to the ethyl gasoline instead of the fumes from tetraethyl lead.

Dr. Lynch, former chief surgeon at Deep Water, is now practicing medicine at Wilmington and occasionally has tetraethyl cases, He was reluctant to discuss the disease because he is no longer associated with the du Ponts, and said he had refrained from publishing a paper dealing with his year's experience in their service for the same reason.

"In several hundred cases which I treated during that first year," he said, "I did not lose one. Durr, who died while I was there, was under the care of his family physician. I had the first cases of the disease ever known. Although it is nervous and mental, neurologists had no clinical background for it. It was a brand new challenge to medical skill.

"We found that nightmares were the first symptom and that these were followed by insomnia. Then came restlessness and inability to eat. Sometimes a patient lost as much as thirty pounds in a few weeks. The blood pressure fell. Frequently they were nauseated. Then came hallucinations. There was no 'wrist drop,' none of the symptoms of the well-known industrial lead poisoning. In the later stages some of the men because suicidal and had to be prevented from destroying themselves."

Charles Hendricks, employed as a painter in the tetraethyl plant, was one worker who tried to kill himself. He jumped from a ferry between Penns Grove and Wilmington last April. He was delirious, and his weight had gone down from 180 pounds to 135. Harry Baker, who was confined at the Salem Hospital, jumped from a window while his male nurse was out of the room, but was caught and returned to his bed. This incident came to public attention and the patient was removed to a private sanitarium at Gladwyn, Pa., where the du Ponts are paying his bills in addition to a bi-weekly allowance to his wife. He is still under treatment.

Precautions in Distribution.

At first tetraethyl lead was shipped